Endocrine Abstracts

We present the case of a 65 year old woman with history of difficult to control essential hypertension for many years, and subarachnoid haemmorhage in 1992 requiring insertion of surgical clips for aneurysms at both internal carotid arteries and right middle cerebral arteries.She presented in 2004 with a 3 week history of headaches and a history over one year of increasing size of her hands, feet and nose, goiter and hoarse voice. Serum IGF-1 was 84 nmol...

A previously well 75 year old man, presented with progressive right sided weakness and ataxia of three months duration that had worsened considerably during the previous 3 weeks. On examination, there was right hemiparesis, marked ataxia, sluggish pupillary responses and an extensive right sided visual field deficit confirmed by formal visual field testing. CT brain large suprasellar mass extending into pituitary fossa. MRI brain confirmed it to be a large pituitary macroadeno...

Objectives: The extent and mechanisms of the diurnal variation in insulin sensitivity are poorly described. This study set out to assess the relative contributions of diurnal rhythm and length of fast to insulin sensitivity in normal healthy human subjects.Methods: Nine healthy women (age 25.3±1.2 years, BMI 22.4±0.8 Kg/m2) ate a standardised meal before each of the four fasts, two ten-hour fasts ending at 0900 and 1700 and two thirteen-hou...

A nineteen-year-old primiparous lady was admitted in her 40th week of gestation with irregular painful contractions. Following a prolonged labour (approx. eighteen hours) she underwent an emergency caesarean section because of decelerations in the foetal heartbeat and meconium staining of her liquor. At a vaginal examination performed pre caesarean to assess the state of her cervix, her clitoris was noted to be enlarged. She delivered a healthy girl who was not virilised. Befo...

Introduction: The treatment of hyperthyroidism is complex. Radio-iodine administration remains the definitive option despite debate regarding optimum dosage and strategy.Method: Thyroid status in all patients receiving first dose radio-iodine over a 5 year period was reviewed at 3, 6, 12 and (most at) 24 months. Radio-iodine doses were individualised depending on thyroid gland size, co-morbidities and patient choice. The objective was euthyroidism with h...